GLP-1s and Peptides for Hashimoto’s Hypothyroidism: What You Must Know
GLP-1 medications like Ozempic and Wegovy have taken the world by storm — but what does that mean for those of us living with Hashimoto’s? In this blog, I’m sharing highlights from my recent interview with McCall McPherson, PA-C, a nationally recognized thyroid and metabolic expert. We sat down to talk about GLP-1s, NAD+, and BPC-157 peptides — and how they fit (or don’t) into the Hashimoto’s healing journey.
If you’re struggling with fatigue, stubborn weight, chronic inflammation, gut issues, or even muscle loss — this post is for you.
Prefer to watch the episode? Catch the full podcast on YouTube here: Watch the Podcast Episode
Why We’re Talking About GLP-1s in the Hashimoto’s Community
Let’s be clear, I’m not here to promote weight loss drugs. I’m a registered dietitian who believes in food-first, root-cause healing. But many people in my community are curious about GLP-1s, peptides, and what they actually do. If you’ve ever asked:
- Are GLP-1s safe for people with autoimmune disease?
- Why am I losing hair and muscle after starting Ozempic?
- Can peptides like BPC-157 really help with gut healing?
- What are the long-term effects on my thyroid?
What Most People Get Wrong About GLP-1s
GLP-1s are NOT just about weight loss. McCall explained that these medications have systemic effects — reducing inflammation, improving insulin sensitivity, calming the immune system, and even lowering autoimmune antibodies in some patients.
The biggest mistake? Taking too much, too fast. Overprescription leads to nausea, hair loss, severe constipation, extreme fatigue, and muscle loss. McCall’s approach is microdosing — starting low and going slow, individualized to each person’s symptoms and biofeedback.
Are GLP-1s Anti-Inflammatory?
Yes. Even one microdose can reduce CRP (a key inflammatory marker) by up to 60%. These effects are being studied for autoimmune conditions including Hashimoto’s, psoriasis, and multiple sclerosis. GLP-1s may lower TPO antibodies and reduce systemic inflammation.
NAD+ and BPC-157 in Autoimmune Care
NAD+
NAD+ is a molecule involved in energy production and mitochondrial function. Supplementing with NAD+ may support:
- Cellular energy
- Brain fog
- Immune resilience
- Inflammation reduction
BPC-157
BPC-157 is a regenerative peptide that helps repair the gut lining and connective tissues. It is often used to support:
- Leaky gut
- Joint injuries
- Post-antibiotic recovery
Should You Consider These Peptides?
These therapies may benefit people with Hashimoto’s when diet and lifestyle changes alone aren’t enough. But it’s essential to work with a knowledgeable provider to minimize risks and monitor progress. The goal is always healing — not just symptom suppression.
Looking for guidance? Check out my Hashimoto’s Healing Blueprint® 30-day program for a structured, supportive path to reducing inflammation and healing from the root.
Conclusion
GLP-1s, NAD+, and BPC-157 are powerful tools when used responsibly. If you’re navigating Hashimoto’s and considering these options, this conversation is for you. Remember, the best healing approach is one that meets your body where it is and supports it holistically.
Questions? Let’s talk. Visit All Purpose Nutrition to book a discovery call.
Prefer a full video? Watch the full episode here on YouTube